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Hair Relaxer Use and Risk of Uterine Leiomyomata in African-American Women
- ↵*Correspondence to Dr. Lauren A. Wise, Slone Epidemiology Center, Boston University, 1010 Commonwealth Avenue, Boston, MA 02215 (e-mail: lwise@bu.edu).
- Received June 15, 2011.
- Accepted September 9, 2011.
Abstract
During 199,991 person-years, 7,146 cases of uterine leiomyomata were reported as confirmed by ultrasound (n = 4,630) or surgery (n = 2,516). The incidence rate ratio comparing ever with never use of relaxers was 1.17 (95% confidence interval (CI): 1.06, 1.30). Positive trends were observed for frequency of use (Ptrend< 0.001), duration of use (Ptrend = 0.015), and number of burns (Ptrend < 0.001).
Among long-term users (≥10 years), the incidence rate ratios for frequency of use categories 3–4, 5–6, and ≥7 versus 1–2 times/year were 1.04 (95% CI: 0.92, 1.19), 1.12 (95% CI: 0.99, 1.27), and 1.15 (95% CI: 1.01, 1.31), respectively (Ptrend = 0.002). Risk was unrelated to age at first use or type of formulation. These findings raise the hypothesis that hair relaxer use increases uterine leiomyomata risk.
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